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Number of 25-μm microspheres traversing the pulmonary circulation and lodging in the kidney in rats, divided based on the venous partial pressure of oxygen (PvO2). More than 100 microspheres were found in the kidneys of animals with PvO2 < 22 mmHg (n = 8, P < 0.001). Transpulmonary passage of microspheres was not seen in rats with PvO2 > 22 mmHg (n = 16).
