Source: Bone HG, Hosking D, Devogelaer JP, Tucci JR, Emkey RD, Tonino RP et al. Ten years’experience with alendronate for osteoporosis in postmenopausal women. New England Journal of Medicine 350(12):1189-99, 2004. Copyright ©2004 Massachusettes Medical Society. All rights reserved.

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• 5 mg alendronate group

♦ discontinued after 2 yrs on 5 mg alendronate

▪ 10-mg alendronate group

Mean +/- standard deviation percent changes in BMD over 10 years at the lumbar spine (A) and total hip (D)

Horizontal line indicates least significant change for a BMD test with precision of 2%