% Change/year in Total Hip Bone Mineral Density (95% Confidence Interval)
	Gained >5% weight	Weight Stable	Lost >5% weight	P-value test for trend
Entire cohort †	0.1 (–0.1, 0.4)	–0.3 (–0.4, –0.3)	–1.4 (–1.6, –1.2)	<.001
BMI<25 kg/m2	0.2 (–0.3, 0.7)	–0.4 (–0.5, –0.2)	–1.4 (–1.9, –0.9)	<.001
BMI 25.0–29.9 kg/m2	0.2 (-0.2, 0.5)	–0.4 (–0.5, –0.3)	–1.2 (–1.5, –0.9)	<.001
BMI >30 kg/m2	–0.2 (–0.8, 0.5)	–0.3 (–0.5, 0.0)	–1.7 (–2.2, –1.2)	<.001
BMI>30 kg/m2, trying to lose weight	0.5 (–0.3, 1.3)	–0.1 (–0.4, 0.1)	–1.7 (–2.4, –1.1)	<.001

^*kg refers to kilogram; m, meter.

^†Adjusted for age, health status, physical activity level, smoking status, alcohol use, total calcium intake, history of one or more select medical conditions (including stroke, diabetes, hyperthyroidism, Parkinson’s disease, coronary heart disease, congestive heart failure, chronic obstructive lung disease, and non skin cancer), body mass index, lean mass, leg power, and total hip bone density.

Used with permission. Ensrud KE, Fullman RL, Barrett-Connor E, Cauley JA, Stefanick ML, Fink HA et al. Voluntary weight reduction in older men increases hip bone loss: the osteoporotic fractures in men study. Journal of Clinical Endocrinology & Metabolism 2005; 90(4):1998-2004. Copright 2005, The Endocrine Society.