Include only RCTs	Clearly defined question	Description of search strategy	Inclusion/exclusion criteria	Study selection & data abstraction by > 1 person	Assessed Quality of Studies	Method of meta-analysis described	Use Individual patient data in Meta-analysis
Wasnich et al., 2000 (64)	√	√	Based on review articles & abstracts	√	NR	NR	√	NR
Cummings et al., 2002 (65)	√	√	√	√	√	NR	√	No
Hochberg et al., 2002 (66)	√	√	NR	√	NR	NR	√	No
Guyatt et al., 2002 (63)	√	√	Not applicable	From meta-analysis	NR	√	√	Summary of meta-analysis
Delmas et al., 2004 (67)	√	√	No, based on studies from another meta-analysis	√	NR	NR	√	√
Watts et al., 2004 (68)	√	√	NR	√ †	NR	NR	√	√
Watts et al., 2005 (69)	√	√	NR	√ †	NR	NR	√	√

^*CI refers to confidence interval; NR, not reported.

^†Provided bases for selecting the 3 trials