Study	Design	Population	Prevalent fractures	Incident fractures
Klotzbuecher et al., 2000 (94)	Meta-analysis 33 studies 1996–1999	peri/postmenopausalwomen	Wrist, vertebral, hip, pooled	Vertebral, hip, wrist, pooled
Kanis et al., 2004 (95)	Meta-analysis(11 large population–based studies 1994–2003	15,259 men and 44,902 women	Prior fractures	Hip, any fracture, osteoporotic fracture (with and without effect of BMD)
Haentjens et al., 2003 (96)	Meta-analysis of 9 cohort studies 1982–2001		Colle’s fractures & spine fractures	Hip fractures
Johnell et al., 2004 (98) Immediately following fracture	Prospective longitudinal cohort study in Sweden 5-year follow-up	1,918 men and women identified by radiology to have a fracture at the spine, hip or shoulder	Spine Hip Shoulder	Relative risk of Hip, spine, and forearm over time stratified by age 60 & age 80 years
Papaioannou et al., 2005 (19) (Post-menopausal women)	Prospective multi-site population based Canadian cohort study 3-year follow-up	5,143 postmenopausal women who participated in the Canadian multicenter Osteoporosis Study mean age of group 66.4 (SD 9.6) –74.4 (SD 10.0) years	Vertebral Forearm Nonvertebral	Vertebral Main nonvertebral (wrist, hip, humerus, pelvis or rib) Any nonvertebral fractures
Bensen et al., 2005 (26) (Canada)	Analysis of prospective multisite Canadian CANDOO database	3,426 postmenopausal women registered in the CANDOO	Previous fractures after age 50 years	OR for vertebral fractures, hip fractures, wrist fracture, & rib fracture
Schousboe et al., 2005 (102)	Study of Osteoporotic Fractures (SOF) - Prospective cohort study in the US Mean follow-up 3.7 years	9,704 elderly community dwelling women, mean age 73.2 years (with wrist fracture) & 71.5 (no wrist fractures)	Previous wrist fractures since age 50 years	Hip fractures Radiographic vertebral fracture
Van der Klift et al., 2004 (103)	Prospective population-based cohort study – Part of the Rotterdam Study Mean follow-up 6.3 years	4,216 men & women (2467 women) age>55 years mean age for subgroups 65.2– 68.6 years	Vertebral fracture	Vertebral fracture
Porthouse et al., 2004 (104)	UK comprehensive cohort study with anested randomized controlled trial on hipprotectors 2 year follow-up	4,292 women ≥ 70 years Mean age 76.9 years	Previous fracture	Hip, nonvertebral, wrist fractures
Taylor et al., 2004 (24)	Study of Osteoporotic Fractures (SOF) - Prospective cohort study in the US	6,787 community-dwelling, ambulatory Caucasian women ≥age 65 (mean age 73.3 (SD 4.9) years from SOF with complete data	Any previous fractures since age 50 years	Hip fractures
Colon-Emeric et al., 2003 (105)	Analysis of data from the Baltimore Hip Studies and the Established Populations for Epidemiologic Studies of the Elderly (EPESE) Mean follow-up 6.0 and 1.6 years respectively	Baltimore study: 549 men & women >/= 65 years of age with acute hip fracture (Mean age 80.9 (SD 7.4) years EPESE: 10,680 community-dwelling men & women age >/= 65 years. Mean age 73.8 (SD 6.7) years	Hip fracture	Hazard ratio for subsequent nonhip skeletal fracture
Naves et al., 2003 (106) (Longitudinal)	Prospective cohort study – Spanish cohort of the EVOS study Follow-up 8 years	316 women and 308 men age> 50 years randomly selected from the EVOS cohort. Mean age 65 (SD 9) for men and women	Prevalent vertebral fracture Prevalent and Incident vertebral fracture Intraobserver agreement = 92%, interobserver agreement of 90%	Hip, Colles’, vertebral Hip, Colles’
Albrand et al., 2003 (OFELY) (25) Healthypostmenopausalwomen	Longitudinal cohort study of healthy ambulatory Caucasian volunteers in Rhone district of France, followed for a mean of 5.3+1.1 years	672 postmenopausal healthy ambulatory Caucasian women (mean age 59.1 years (SD 9.8 years)	All prevalent fractures after age 45 years	Fragility fractures
Pongchaiyakul et al., 2005 (99)	Part of ongoing Dubbo Osteoporosis Epidemiology study (DOES) – longitudinal, population-based study of risk factors for fracture & mortality in Australia (5 year follow-up)	114 men and 186 women (age> 60 years & free of illnesses that affect bone metabolism) randomly selected from the DOES database Mean age 69.8 years with vertebral deformity) & 69.4 years with no vertebral deformity	Asymptomatic vertebral deformity (at least –3SD in vertebral height) confirmed on radiograph	Any fracture Hip fracture Vertebral fracture Colles’ fracture Major fractures (major upper or lower limb and/or rib fractures)
Hasseius et al., 2003 EVOS (101) Longitudinal	European Vertebral Osteoporosis Study – multicenter study to evaluate vertebral deformity – men and women followed for 10 years	Men & women age 50–80 years 213 men (mean age 63 years) and 257 women (mean age 64 years)	Vertebral deformity (–3 SD or –5 SD in vertebral height	Any incident fracture Any fragility fracture
Szulc et al., 2005 (97)	A prospective study of osteoporosis and of its determinants in men (MINOS) in France Follow-up 7.5 years	791 men aged 51-85 years were followed prospectively for BMD and fractures	Prevalent fractures	Fractures Total hip fractures