Table 1: Quality of Evidence of Included Studies*.
| Study Design | Level of Evidence |
Number of Eligible Studies |
|---|---|---|
| Large RCT, systematic reviews of RCT | 1 | 6, 3 |
| Large RCT unpublished but reported to an international scientific meeting | 1(g) | 0 |
| Small RCT | 2 | 0 |
| Small RCT unpublished but reported to an international scientific meeting | 2(g) | 0 |
| Non-RCT with contemporaneous controls | 3a | 7 |
| Non-RCT with historical controls | 3b | 0 |
| Non-RCT presented at international conference | 3(g) | 0 |
| Surveillance (database or register) | 4a | 1 |
| Case series (multisite) | 4b | 0 |
| Case series (single site) | 4c | 0 |
| Retrospective review, modeling | 4d | 2 |
| Case series presented at international conference | 4(g) | 0 |
*
RCT refers to randomized controlled trial; g, non-peer-reviewed grey literature.