Table 7: Adverse Events in MUST-EECP.(33).
| Adverse Events | Inactive-CP (n=66) |
Active-CP (n=71) |
P value |
|---|---|---|---|
| Number of patients with adverse events | 17(25.8%) | 39(54.9%) | <0.001 |
| Non-device related | |||
| Viral syndrome | 0 | 1 | >0.5 |
| Anxiety | 0 | 2 | =0.5 |
| Dizziness | 1 | 3 | >0.5 |
| Tinnitus | 0 | 1 | >0.5 |
| GI disturbance | 1 | 1 | >0.5 |
| Headache | 0 | 1 | >0.5 |
| Blood pressure change | 1 | 1 | >0.5 |
| Epistaxis | 0 | 2 | =0.5 |
| Angina | 1 | 1 | >0.5 |
| “Other” chest pain | 3 | 9 | =0.3 |
| A/V arrhythmia | 3 | 9 | >0.2 |
| Heart rate change (sinusal) | 3 | 0 | =0.1 |
| Respiratory | 2 | 4 | >0.5 |
| Total non-device related | 15 | 33 | <0.005 |
| Device related | |||
| Paresthesia | 1 | 2 | >0.5 |
| Edema, swelling | 0 | 2 | =0.5 |
| Skin abrasion, bruise, blister | 2 | 13 | =0.005 |
| Pain (legs, back) | 7 | 20 | =0.01 |
| Total device related | 10 | 37 | <0.001 |
Reprinted from the Journal of the American College of Cardiology, v. 33, Arora RR, Chou TM, Jain D, Fleishman B, Crawford L, McKiernan T, Nesto RW. The multicenter study of enhanced external counterpulsation (MUST-EECP): effect of EECP on exercise induced myocardial ischemia and anginal episodes, 1833-1840, Copyright 1999, with permission from the American College of Cardiology Foundation.