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Illustration of how a fixed dose ratio combination of 2 agonist drugs are used in a calculation of the expected (additive effect) of a combination dose. The graphs are shown for 3 different fixed ratio dose combinations and are expressed and plotted in terms of the dose a of the lower efficacy drug. The drug parameters are for Drug A, E A = 60, C A = 100; for Drug B, E B = 100, C B = 20. Details of the calculation of the combined effect are given in the text.
