Table 3.
Comparison of melanoma patients with brain metastasis as isolated first visceral site versus all other patients
| Characteristic | Cohort 1 |
Pd | Cohort 2 |
Pd | Pce | ||
|---|---|---|---|---|---|---|---|
| Brain Metastasis as Isolated First Visceral Site | Other Metastasis or No Metastasisa | Brain Metastasis as Isolated First Visceral Site | Other Metastasis or No Metastasisa | ||||
| (n= 40) | (n = 1003) | (n = 34)b | (n = 1203)c | ||||
| n (%) | n (%) | n (%) | n (%) | ||||
| Primary tumor thickness (mm) | .0017f | .0002f | <.0001 | ||||
| Median (range) | 2.20 (0.50–10) | 1.30 (0.10–15) | 1.61 (0.52–30) | 0.96 (0.12–30) | |||
| Primary tumor ulceration status | .0002 | <.0001 | <.0001 | ||||
| Absent | 21 (52.5%) | 758 (75.6%) | 15 (50.0%) | 937 (81.0%) | |||
| Present | 19 (47.5%) | 218 (21.7%) | 15 (50.0%) | 217 (18.8%) | |||
| Unclassified | 0 (0.0%) | 27 (2.7%) | 0 (0.0%) | 3 (0.3%) | |||
| Primary tumor mitosis | .20 | .10 | .10 | ||||
| Absent | 11 (27.5%) | 361 (36.0%) | 6 (20.0%) | 389 (33.6%) | |||
| Present | 26 (65.0%) | 533 (53.1%) | 23 (76.7%) | 715 (61.8%) | |||
| Unclassified | 3 (7.5%) | 109 (10.9%) | 1 (3.3%) | 53 (4.6%) | |||
| AJCC stage at pathological diagnosis | .007 | .001 | <.0001 | ||||
| I | 16 (40.0%) | 618 (61.6%) | 13 (38.2%) | 775 (64.4%) | |||
| II | 13 (32.5%) | 267 (26.6%) | 8 (23.5%) | 215 (17.9%) | |||
| III | 11 (27.5%) | 106 (10.6%) | 9 (26.5%) | 188 (15.6%) | |||
| IV | 0 (0.0%) | 4 (0.4%) | 4 (11.8%) | 25 (2.1%) | |||
| Unable to assess | 0 (0.0%) | 8 (0.8%) | 0 (0.0%) | 0 (0.0%) | |||
| Primary tumor histologic subtype | .04 | .0002 | .0001 | ||||
| Nodular | 8 (20.0%) | 109 (10.9%) | 17 (56.7%) | 304 (26.3%) | |||
| Superficial spreading/other | 25 (62.5%) | 792 (79.0%) | 12 (40.0%) | 805 (69.6%) | |||
| Unclassified | 7 (17.5%) | 102 (10.2%) | 1 (3.3%) | 48 (4.1%) | |||
Unclassified data were removed before the chi–square test or Fisher's exact test was applied.
aIncludes patients with visceral metastasis: extracranial only or extracranial and brain as well as patients with no visceral metastasis.
b4 unknown primaries.
c46 unknown primaries.
dBy the Wilcoxon–Mann–Whitney test or Kruskal–Wallis test for continuous variables and the chi–square test or Fisher's exact test for categorical variables.
eCombined Fisher P value for comparing patients with brain metastasis as isolated first visceral site and all other patients.
fAnalyzed as a continuous variable.