Fig. 7.

Effects of PD0332991 on intracranial tumors. (A) Kaplan–Meier survival curves of mice with established intracranial tumor GBM6 that were randomized to therapy with placebo (n = 10) or PD0332991 (n = 10). Difference between survival curves were compared using a log-rank test and shown as P value. (B) Immunohistochemistry of Ki67 and phospho-Rb in tumor sections from GBM6 implanted mice treated with placebo or PD0332991. Mice with established intracranial tumors were randomized to therapy with placebo or PD0332991 for 6 days before euthanasia and processing of brain samples for immunostaining. Bar graphs show the effects of treatment on Ki67 labeling and phospho-Rb inhibition. Mean ± SD from 9 mice for each indicated group. **P< .001 vs. placebo group.