TABLE 3.
Tumor Response in Relation to EGFR FISH, HER2 FISH, EGFR Mutation and KRAS Mutation Status
| Patients | Tumor response | ||||||
|---|---|---|---|---|---|---|---|
| Molecular marker | Categories | n | % | PR (%) | SD | PD | p |
| EGFR | Positive (+) | 20 | 61 | 13 (65%) | 1 | 6 | p = 0.0777 |
| Negative (−) | 13 | 39 | 4 (29%) | 0 | 9 | ||
| HER2 | Positive (+) | 17 | 52 | 8 (47%) | 0 | 9 | p = 0.4426 |
| Negative (−) | 16 | 48 | 9 (56%) | 1 | 6 | ||
| EGFR and HER2 | +/+ | 13 | 39 | 8 (62%) | 0 | 5 | p = 0.2451 |
| +/− | 7 | 21 | 5 (71%) | 1 | 1 | ||
| −/+ | 4 | 12 | 0 (0%) | 0 | 4 | pa | |
| −/− | 9 | 27 | 4 (44%) | 0 | 5 | ||
| EGFR mutation | Positive (+) | 20 | 61 | 17 (85%) | 1 | 2 | p = 0.0001 |
| Negative (−) | 13 | 39 | 0 (0%) | 0 | 13 | ||
| EGFR FISH and EGFR mutation | +/+ | 16 | 48 | 13 (81%) | 1 | 2 | p = 0.0029 |
| +/− | 4 | 12 | 0 (0%) | 0 | 4 | ||
| −/+ | 4 | 12 | 4 (100%) | 0 | 0 | pa | |
| −/− | 9 | 27 | 0 (0%) | 0 | 9 | ||
| KRAS mutation | Positive (+) | 4 | 13 | 0 (0%) | 0 | 4 | p = 0.0995 |
| Negative (−) | 26 | 87 | 14 (54%) | 1 | 11 | ||
| EGFR FISH and KRAS mutation | +/+ | 0 | 0 | 0 (0%) | 0 | 0 | pa |
| +/− | 17 | 57 | 10 (59%) | 1 | 6 | ||
| −/+ | 4 | 13 | 0 (0%) | 0 | 4 | pa | |
| −/− | 9 | 30 | 4 (44%) | 0 | 5 | ||
FISH, fluorescence in situ hybridization; EGFR, epidermal growth factor receptor; PR, partial response; PD, progressive disease.
a
p value could not be calculated because of blank cells.