Table 1.

Natural Sensitivity to Benznidazole Is Not Associated With TcNTR Sequence

Haplotype, Strain	GenBank Accession No.	Biological Origin	Geographical Origin	Phylogenetic Group	IC50, μM
Haplotype 1
AC17	JN043349	Rhodnius pallescens	Chocó	I	6.53 ± 1.12
AMP07	JN043351	Panstrongylus geniculatus	Antioquia	I	17.6 ± 0.3
B114	JN043353	Triatoma dimidiata	Córdoba	I	18.7 ± 1.4
B138	JN043352	T. dimidiata	Córdoba	I	17.6 ± 0.7
B51	JN043354	R. pallescens	Córdoba	I	20.6 ± 1.1
CAS18	JN043345	Didelphis marsupialis	Casanare	I	3.90 ± 0.78
CG	JN043336	Homo sapiens	Caquetá	II	4.61 ± 0.35
GAL52	JN043347	D. marsupialis	Sucre	I	9.07 ± 2.06
GAL61	JN043346	Rattus rattus	Sucre	I	5.85 ± 1.51
HA	JN043337	H. sapiens	Casanare	I	4.66 ± 0.61
LB53	JN043358	T. dimidiata	Sucre	I	17.0 ± 0.7
MG	JN043339	H. sapiens	Arauca	I	4.90 ± 0.33
MG10	JN043356	T. dimidiata	Magdalena	I	14.9 ± 0.89
OV1	JN043359	P. geniculatus	Sucre	I	17.4 ± 0.76
OV17	JN043355	P. geniculatus	Sucre	I	22.2 ± 2.4
SN3	JN043361	Rhodnius prolixus	La Guajira	I	34.6 ± 1.9
SN5	JN043360	R. prolixus	La Guajira	I	24.2 ± 1.3
SN6	JN043357	R. prolixus	La Guajira	I	16.9 ± 0.9
SP	JN043342	H. sapiens	Casanare	I	6.41 ± 0.75
SPR	JN043341	H. sapiens	Casanare	II	5.32 ± 1.08
STP33	JN043350	R. prolixus	Tolima	I	11.3 ± 1.0
Haplotype 2
AF1	JN043348	P. geniculatus	Antioquia	II	4.69 ± 1.87
JEM	JN043340	H. sapiens	Putumayo	I	5.19 ± 0.65
Distinct haplotypes
DA	JN043344	H. sapiens	Boyacá	I	32.8 ± 3.3
FCH	JN043334	H. sapiens	N.de Santander	II	1.50 ± 0.51
MR	JN043338	H. sapiens	Cesar	II	4.71 ± 0.29
W3534	JN043343	H. sapiens	Sucre	I	14.0 ± 1.3
YLY	JN043335	H. sapiens	Putumayo	I/II	4.38 ± 0.24

TcNTR genes were amplified from DNA of 28 Colombian Trypanosoma cruzi strains and sequenced.

Abbreviation: IC₅₀, median inhibitory concentration.