Figure 5.
Clinical effects of 3-year extension study of lanthanum carbonate therapy in Japanese hemodialysis patients. (A) The mean serum phosphate (Pi) level was 8.03 ± 1.51 mg/dL at baseline, and it decreased to 5.33 ± 1.27 mg/dL and 5.33 ± 1.04 mg/dL after 1 year and 3 years of treatment, respectively. The mean reduction of Pi from baseline was within the range of –1.51 ± 1.48 mg/dL in week 1 (95% CI: −1.76, −1.27) to −3.08 ± 1.76 mg/dL in week 128 (95% CI: −3.69, −2.47). (B) The calcium (Ca)-Pi product has been well controlled below 55.0 (mg/dL)2 dependent on serum Pi level. (C) On the other hand, the intact parathyroid hormone (PTH) level was elevated overall and then stable throughout the treatment period, with a median value of 262.0 pg/mL at baseline and 283.8 pg/mL at 3 years.
Note: From Shigematsu21 with permission from Springer Japan and the Japanese Society of Nephrology.