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. Author manuscript; available in PMC: 2012 Jun 20.
Published in final edited form as: Physiol Rev. 2011 Apr;91(2):389–411. doi: 10.1152/physrev.00007.2010

FIGURE 1. Model of CNS regulation of glucose homeostasis.

FIGURE 1

The CNS integrates signals from both long-term energy stores (e.g. leptin) and short-term availability (nutrients; e.g. free fatty acids) and orchestrates responses that coordinate hepatic glucose production, peripheral glucose uptake and insulin secretion to maintain glucose homeostasis.