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. Author manuscript; available in PMC: 2012 Jun 20.
Published in final edited form as: J Surg Res. 2009 Jul 12;161(1):28–32. doi: 10.1016/j.jss.2009.06.013

Figure 5.

Figure 5

Growth inhibition is accompanied by cleavage of PARP, a marker of apoptosis. A. MiaPaCa-2 cells were treated with ZM336372 for 48 hours. A dose-dependent increase in cleaved PARP (cPARP) was observed. No observable cPARP at the 25μM concentration. B. Panc-1 cells treated with ZM336372 for 48 hours also resulted in PARP cleavage. Minimal cPARP was observed at the 25μM concentration and increases in a dose-dependent manner. A and B were performed using a specific cleaved PARP antibody. C. LiCl treatment of MiaPaCa-2 cells was performed. PARP cleavage occurred with the 20mM concentration. This correlates with the MTT growth assay.