Table 3.
Editing efficiencies of the ionotropic glutamate receptors in the human dorsolateral prefrontal cortex, by diagnosis and manner of death
| Target | Entire cohort, n = 99 | Diagnostic group; mean (SEM)* | Manner of death; mean (SEM)* | |||
|---|---|---|---|---|---|---|
|
| ||||||
| Control, n = 34 | Bipolar disorder, n = 31 | Schizophrenia, n = 34 | Nonsuicide, n = 78 | Suicide, n = 21 | ||
| GluA2 flip R/G | 55.8 (0.8) | 56.7 (1.3) | 55.1 (1.2) | 55.4 (1.5) | 55.7 (0.9) | 56.5 (1.4) |
| GluA2 flop R/G | 55.7 (0.5) | 56.2 (0.6) | 55.9 (0.6) | 55.0 (1.0) | 55.5 (0.5) | 56.7 (0.6) |
| GluA2 Q/R | 96.1 (0.2) | 95.7 (0.3) | 96.2 (0.3) | 96.6 (0.2) | 96.2 (0.2) | 96.0 (0.3) |
| GluA3 flip R/G | 92.8 (0.3) | 92.5 (0.7) | 92.8 (0.5) | 93.1 (0.4) | 92.8 (0.4) | 92.8 (0.6) |
| GluA3 flop R/G | 93.8 (0.2) | 93.8 (0.4) | 94.1 (0.3) | 93.7 (0.3) | 93.8 (0.2) | 93.9 (0.4) |
| GluA4 flip R/G | 61.7 (1.5) | 61.4 (2.7) | 61.6 (2.4) | 62.0 (2.6) | 61.8 (1.7) | 60.4 (3.1) |
| GluA4 flop R/G | 99.5 (0.1) | 99.6 (0.1) | 99.6 (0.1) | 99.4 (0.1) | 99.5 (0.1) | 99.7 (0.1) |
| GluK1 Q/R | 59.8 (0.5) | 60.3 (0.6) | 59.0 (0.8) | 60.0 (1.0) | 59.8 (0.6) | 60.1 (1.0) |
| GluK2 Q/R | 81.2 (0.4) | 80.8 (0.7) | 80.8 (0.7) | 81.9 (0.5) | 81.2 (0.4) | 81.2 (0.8) |
| GluK2 I/V | 49.3 (0.7) | 50.7 (1.0) | 48.5 (1.1) | 48.6 (1.3) | 49.1 (0.8) | 49.9 (1.5) |
| GluK2 Y/C | 80.8 (0.6) | 80.4 (0.3) | 80.7 (0.5) | 80.3 (0.5) | 80.1 (0.5) | 80.2 (0.3) |
I/V = isoleucine-to-valine site; Q/R = glutamine-to-arginine; R/G = arginine-to-glycine site; SEM = standard error of the mean; Y/C = tyrosine-to-cysteine site.
*
Means represent % edited.