Table 3.
Top left-right atria differentially regulated genesets by presence of transcription factor binding motifs ± 2 kb from the start site of transcription of atrial expressed genes.
| Motif | Right* | Left* | Hypothesis |
|---|---|---|---|
| V$AP4_01 | 19 | 10 | Right |
| AACTTT_UNKNOWN | 195 | 74 | Right |
| AACWWCAANK_UNKNOWN | 10 | 1 | Right |
| V$P300_01 | 25 | 7 | Right |
| V$CREBP1_01 | 14 | 6 | Right |
| V$MYOGNF1_01 | 6 | 3 | Right |
| V$IRF1_01 | 23 | 9 | Right |
| V$IRF2_01 | 10 | 5 | Right |
| V$TAL1BETAE47_01 | 24 | 12 | Right |
| V$TAL1ALPHAE47_01 | 24 | 11 | Right |
| V$HEN1_01 | 21 | 12 | Right |
| V$TAL1BETAITF2_01 | 26 | 14 | Right |
| V$GATA3_01 | 24 | 13 | Right |
| V$EVI1_04 | 34 | 6 | Right |
| V$EVI1_05 | 17 | 7 | Right |
| V$MZF1_02 | 19 | 6 | Right |
| V$ZID_01 | 21 | 8 | Right |
| V$IK2_01 | 28 | 7 | Right |
| V$CDP_01 | 7 | 4 | Right |
| ACCTGTTG_UNKNOWN | 15 | 5 | Right |
| V$ELK1_02 | 3 | 8 | Right |
| V$CREB_01 | 14 | 16 | Left |
| V$EVI1_02 | 7 | 7 | Left |
| V$NRF2_01 | 3 | 8 | Left |
| ACTAYRNNNCCCR_UNKNOWN | 9 | 10 | Left |
| V$USF_C | 12 | 14 | Left |
| V$PPARA_01 | 3 | 4 | Left |
| V$ATF_B | 11 | 13 | Left |
| V$GABP_B | 3 | 8 | Left |
| V$TEL2_Q6 | 14 | 4 | Left |
| V$SF1_Q6 | 19 | 13 | Left |
| V$COUP_DR1_Q6 | 13 | 11 | Left |
| GGAANCGGAANY_UNKNOWN | 0 | 9 | Left |
| V$CREB_Q4_01 | 11 | 12 | Left |
| V$AP4_Q6_01 | 16 | 23 | Left |
| V$ER_Q6_02 | 18 | 25 | Left |
Inclusion in this table was performed by filtering genesets that contained at least 5 genes that were significantly up regulated in the right or left atria, and by having the minimum p-value (10−4) under the model-free hypothesis including all genes near the specified DNA element.
*
Number of genes from the geneset that are contained within those found to be expressed significantly higher in the left or right atria via the edgeR analysis (FDR < 0.05), not including those with moderate expression bias.