Table 2.
In Vitro antibacterial activities of the siderophore-β-lactam conjugates 10 and 11 (MIC in μM).
| 10 | 11 | Ampicillin | Amoxcillin | |||||
|---|---|---|---|---|---|---|---|---|
|
|
||||||||
| +Fe | −Fe | +Fe | −Fe | +Fe | −Fe | +Fe | −Fe | |
| P. aeruginosa KW799/wt | 33 | 0.05 | 25 | 0.05 | >200 | >200 | >200 | >200 |
| P. aeruginosa KW799/61 | 12.5 | 0.067 | 12.5 | 0.083 | 0.52 | 0.78 | 0.46 | 0.39 |
| P. aeruginosa PAO1 | 50 | 0.39 | 50 | 0.39 | >200 | >100 | >200 | >100 |
| P. aeruginosa Pa4 | 25 | 0.39 | 25 | 0.21 | >200 | >100 | >200 | >100 |
| P. aeruginosa Pa6 | >200 | >200 | >200 | >200 | >200 | >200 | >200 | >200 |
| E.coli ATCC 25922 | 150 | 1.56 | 100 | 6.25 | 16.7 | 12.5 | 4.17 | 4.17 |
| K.pneumoniae ATCC 8303 ×68 | >200 | >100 | >200 | >100 | >200 | >100 | 100 | >100 |
aMIC90 values (μM) were determined using the broth microdilution method in Mueller-Hinton broth No.2 (MHII) with visual end point analysis according to the CLSI guidelines.
bEach compound was tested in triplicate.