Table 1.

Framingham Heart Study: Comparing the cumulative incidences (unadjusted for alternative cause mortality) and the 25-year and 40-year residual lifetime risks (adjusted for mortality due to competing causes) of Alzheimer’s dementia in persons who are cognitively intact at age 65 years based on variation in severity required to diagnose clinical dementia

Period of follow-up	1975 to 1995	1975 to 2008
Outcome used	Age at onset	Age at diagnosis	Age at diagnosis
Severity required for clinical diagnosis	Moderate +	Moderate +	Mild +
Number demented	141	353	388
Cumulative incidence
25 year	14.4	12.2	20.9
40 year	29.9	62.3	66.6
Residual lifetime risk
25 year	8.9	8.7	11.1
40 year	11.8	13.5	15.3

Reprinted from Alzheimer’s and Dementia: Seshadri S, Beiser A, Au R et al. Operationalizing diagnostic criteria for Alzheimer's disease and other age-related cognitive impairment-Part 2. Alzheimers Dement. 2011 Jan;7(1):37 with permission from Elsevier