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Sequence of the proximal CRH promoter (−254 bp to −55 bp) showing the CpG dinucleotides (in red) present in this region. The numbers following each CpG identify the dinucleotides subjected to methylation analysis. TSP: Transcription start point; TBP: TATA binding protein site; GAGA: GAGA factor site; CRE: cyclic AMP response element. CRE is located at −230 bp to −222 bp. CpG1 is located just beside of CRE at −232bp and CpG2 is located inside of CRE at −226 bp.
