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. Author manuscript; available in PMC: 2013 Jul 1.
Published in final edited form as: J Neuroendocrinol. 2012 Jul;24(7):1055–1064. doi: 10.1111/j.1365-2826.2012.02306.x

Fig. 5.

Fig. 5

Methylation analysis of the CpG dinucleotide island within the rat CRH promoter region in the hypothalamic paraventricular nucleus of female (A) and male (B) rats. In PVN of MD rats, significantly lower methylation of CpG#1 (C) and CpG#2 (D) at −230 bp the cyclic AMP-responsive element of the CRH promoter was observed. Bars represent the average ± S.E.M of values obtained in 9 to 11 rats per group. Differences were not significant in the overall analysis by two-way-ANOVA. The pooled data for male and females for CpG1 and CpG2 are shown in C and D, respectively. * P< 0.05, MD vs controls by Student’s t test analysis.