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. Author manuscript; available in PMC: 2013 Jul 1.
Published in final edited form as: J Neuroendocrinol. 2012 Jul;24(7):1055–1064. doi: 10.1111/j.1365-2826.2012.02306.x

Fig. 7.

Fig. 7

Effect of methylation at CpGs immediately preceding (metC-1) or within (metC-2) the CRE, or methylation of both CpGs (metC1&2), on phospho-CREB (pCREB) binding to CRH promoter oligonucleotides. The sequence of the oligonucleotide is shown in A, and a representative image of a gel is shown in B. Bars represent the mean ± S.E.M of values obtained from shifted (filled bars) and super-shifted (open bars) bands in three experiments (C). *P< 0.05 compared to wild type oligonucletide (WT) (one-way ANOVA analysis).