Table 3.

Relationship between CYP4A11 T8590C Genotype and HDL-C in Unrelated Sample from Framingham Offspring Study

		LS Mean HDL-C
		CC or CT	TT	Unadjusted P	Adjusted P*
Visit 1	Women	54.9±1.1	57.6±0.6	0.03	0.12
	Men	44.6±0.8	44.5±0.5	0.84	0.74
	Combined	49.6±0.8	51.1±0.4	0.09	0.15
Visit 2	Women	52.3±1.1	54.9±0.6	0.04	0.13
	Men	43.0±0.8	43.0±0.5	0.92	0.85
	Combined	47.3±0.8	48.9±0.4	0.06	0.17
Visit 3	Women	55.3±1.2	57.9±0.7	0.05	0.27
	Men	44.3±0.9	44.9±0.5	0.55	0.96
	Combined	49.5±0.8	51.3±0.5	0.06	0.43
Visit 4	Women	54.5±1.2	56.6±0.6	0.12	0.31
	Men	43.6±0.8	43.1±0.5	0.61	0.67
	Combined	48.8±0.8	49.8	0.24	0.51
Visit 5	Women	53.4±1.2	56.7±0.6	0.01	0.02
	Men	43.0±0.8	42.9±0.5	0.86	0.88
	Combined	48.0±0.8	49.9±0.4	0.03	0.06
Visit 6	Women	55.8±1.2	58.2±0.7	0.09	0.28
	Men	43.4±0.9	43.5±0.5	0.92	0.88
	Combined	49.4±0.8	50.9±0.5	0.10	0.26

HDL-C indicates high density lipoprotein cholesterol. Data are presented as estimated means ± standard error.

^*Adjusted for exam-specific age, age², body mass index, number of cigarettes smoked per day, ounces of alcohol consumed per week and menopausal status and estrogen status in women.