Table 4.

Relationship between CYP4A11 T8590C Genotype and HDL-C in Combined Unrelated and Family Sample from Framingham Offspring Study

		LS Mean HDL-C
		CC or CT	TT	Unadjusted P	Adjusted P*
Visit 1	Women	54.9±0.9	57.4±0.5	0.01	0.06
	Men	44.4±0.7	44.4±0.4	0.95	1.00
	Combined	49.9±0.6	51.2±0.4	0.07	0.1
Visit 2	Women	52.1±0.8	54.8±0.5	0.004	0.02
	Men	42.8±0.7	43.0±0.4	0.78	0.76
	Combined	47.6±0.6	49.1±0.4	0.02	0.04
Visit 3	Women	55.5±0.9	57.9±0.5	0.02	0.07
	Men	44.3±0.7	45.0±0.5	0.34	0.68
	Combined	50.1±0.6	51.6±0.4	0.047	0.09
Visit 4	Women	54.2±0.9	57.9±0.5	0.02	0.07
	Men	42.9±0.7	43.2±0.4	0.62	0.88
	Combined	48.7±0.6	50.2±0.4	0.048	0.11
Visit 5	Women	54.4±0.9	56.7±0.5	0.02	0.03
	Men	42.6±0.7	43.0±0.4	0.563	0.42
	Combined	48.8±0.6	50.3±0.4	0.05	0.04
Visit 6	Women	55.6±0.9	58.6±0.6	0.005	0.02
	Men	42.8±0.7	43.6±0.4	0.324	0.33
	Combined	49.5±0.7	51.5±0.4	0.01	0.01

HDL-C indicates high density lipoprotein cholesterol. Data are presented as estimated means ± standard error.

^*Adjusted for exam-specific age, age², body mass index, number of cigarettes smoked per day, ounces of alcohol consumed per week and menopausal status and estrogen status in women.