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Formation of acyl glucuronide M3 by recombinant human UGTs. MK-7246 at 5 and 50 µmol/l MK-7246 were incubated with UGTs in the presence of UDPGA for 90 min. Each bar and error bar represents the mean and standard deviation, respectively, of determinations carried out in triplicate. HLM, human liver microsome; UDPGA, uridine 5′-diphospho-glucuronic acid; UGT, uridine 5′-diphosphate-glucuronosyltransferase.
