Table 1.
Genes downregulated by benfotiamine
| Symbol | Acc | Description | FC NG | FC HG |
|---|---|---|---|---|
| LRRN1 | NM_020873 | Leucine rich repeat neuronal 1 | −3.97 | −3.43 |
| RARRES1 | NM_206963 | Retinoic acid receptor responder (tazarotene induced) 1 | −3.62 | −2.50 |
| COMP | NM_000095 | Cartilage oligomeric matrix protein | −3.39 | −4.48 |
| COL15A1 | NM_001855 | Collagen. type XV, alpha 1 | −3.29 | −3.10 |
| SPRR2G | NM_001014291 | Small proline-rich protein 2G | −3.28 | −2.85* |
| MDK | NM_001012333 | Midkine (neurite growth-promoting factor 2) | −3.23 | −3.34 |
| COL16A1 | NM_001856 | Collagen. type XVI, alpha 1 | −3.18 | −3.05 |
| TYMP | NM_001953 | Thymidine phosphorylase | −2.89 | −2.20* |
| PACSIN1 | NM_020804 | Protein kinase C and casein kinase substrate in neurons 1 | −2.89 | −2.30 |
| MYOT | NM_006790 | Myotilin | −2.86 | −2.40* |
| FAM180B | XM_001716425 | Family with sequence similarity 180, member B | −2.81 | −3.25 |
| FRAS1 | NM_025074 | Fraser syndrome 1 | −2.75 | −2.88 |
| MGC16121 | XM_001128419 | Hypothetical protein MGC16121 | −2.68 | −1.45* |
| MXRA5 | NM_015419 | Matrix-remodeling associated 5 | −2.67 | −2.72 |
| SORBS2 | NM_021069 | Sorbin and SH3 domain containing 2 | −2.66 | −2.96 |
| HES4 | NM_021170 | Hairy and enhancer of split 4 (Drosophila) | −2.57 | −2.43 |
| NOX4 | NM_016931 | NADPH oxidase 4 | −2.56 | −3.07 |
| CTHRC1 | NM_138455 | Collagen triple helix repeat containing 1 | −2.54 | −1.90 |
| CHN2 | NM_004067 | Chimerin (chimaerin) 2 | −2.53 | −1.95* |
| CIRBP | NM_001280 | Cold-inducible RNA-binding protein | −2.51 | −1.94* |
[20 genes with greatest fold change (FC) decreased after benfotiamine treatment (200 μM, 4 days) as compared to cells not exposed to benfotiamine under NG conditions, with corresponding values under HG conditions], adjusted P value < 0.1
* Adjusted P value ≥ 0.1. N = 3 in each group