Table 2.
Genes upregulated by benfotiamine
| Symbol | Acc | Description | FC NG | FC HG |
|---|---|---|---|---|
| SERPINB7 | NM_003784 | Serpin peptidase inhibitor, clade B (ovalbumin), member 7 | 3.39 | 2.27 |
| MX1 | NM_002462 | Myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse) | 3.19 | 3.32* |
| CPA4 | NM_016352 | Carboxypeptidase A4 | 3.16 | 1.57* |
| TM4SF4 | NM_004617 | Transmembrane 4 L six family member 4 | 3.11 | 2.14* |
| LCE3D | NM_032563 | Late cornified envelope 3D | 2.76 | 2.54 |
| IFI44L | NM_006820 | Interferon-induced protein 44-like | 2.62 | 2.54 |
| PSG4 | NM_213633 | Pregnancy specific beta-1-glycoprotein 4 | 2.43 | 1.98 |
| TSGA10 | NM_182911 | Testis specific, 10 | 2.38 | 2.55 |
| NRXN2 | NM_138732 | Neurexin 2 | 2.32 | 1.95 |
| MT1G | NM_005950 | Metallothionein 1G | 2.32 | 1.44 |
| CCL26 | NM_006072 | Chemokine (C–C motif) ligand 26 | 2.18 | 1.60* |
| HCG_1815504 | XM_498560 | HCG1815504 | 2.15 | 1.85* |
| BRE | NM_199193 | Brain and reproductive organ-expressed (TNFRSF1A modulator) | 2.12 | 1.79 |
| PSG11 | NM_002785 | Pregnancy specific beta-1-glycoprotein 11 | 2.11 | 1.42* |
| TFPI | NM_001032281 | Tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | 2.10 | 1.40* |
| EVI2A | NM_001003927 | Ecotropic viral integration site 2A | 2.10 | 1.69* |
| ALDH3A1 | NM_000691 | Aldehyde dehydrogenase 3 family. memberA1 | 2.09 | 2.13 |
| FGGY | NM_001113411 | FGGY carbohydrate kinase domain containing | 2.02 | 1.95 |
| DEFB103B | NM_001081551 | Defensin, beta 103B | 2.01 | 1.27* |
| IFI44 | NM_006417 | Interferon-induced protein 44 | 1.98 | 2.07* |
[20 genes with greatest fold change (FC) increased after benfotiamine treatment (200 μM, 4 days) as compared to cells not exposed to benfotiamine under NG conditions, with corresponding values under HG conditions], adjusted P value < 0.1
*Adjusted P value ≥ 0.1. N = 3 in each group