Table 3.
Number of regulated gene sets comparing control and benfotiamine treatment within each group under normoglycemic (NG) conditions (paired GSEA analysis, score: log-fold change, FDR ≤ 5%)
| Gene set collections | Number of gene sets in collection | Control > benfotiamine (downregulated by treatment) | Benfotiamine > control (upregulated by treatment) |
|---|---|---|---|
| C5 bp | 753 | 1 | 0 |
| C3TFT | 582 | 5 | 0 |
| C2 | 846 | 2 | 7 |
| Energy | 63 | 5 | 1 |
| Glucose | 63 | 0 | 1 |
| Insulin | 97 | 0 | 0 |
| Lipid | 141 | 1 | 11 |
| DNA and repair | 77 | 0 | 0 |
| Interleukin | 133 | 1 | 0 |
| Lactate | 5 | 0 | 0 |
| Mitochondria | 29 | 0 | 0 |
| Transportera | 29 | 2 | 0 |
A gene set browser provided by Broad institute at http://www.broad.mit.edu/gsea/was used to obtain the stress-associated gene set collections. Detailed information regarding the regulated gene sets and leading edge genes is given in online supplementary table s3
a Indicates that truncated search keyword was used to create the gene set collections. C2, C3TFT and C5 are predefined gene set collections. N = 3 in each group