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Wnts are involved in synaptogenesis by promoting synapse formation. (A) In the cerebellum, Wnt7a acts as a retrograde signal to regulate presynaptic assembly through Dvl- and Gsk3β-mediated signalling pathways. (B) In hippocampal neurons, Fz5 is required for Wnt7a-mediated synapse formation. The activation of Wnt7a increases presynaptic inputs, whereas the activation of Wnt5a decreases the number of presynaptic terminals.
