Figure 4.

Diffusion tensor imaging (DTI) findings. Top panel: (A) shows areas of significant fractional anisotropy (FA) reduction in the schizophrenic patients identified using Tract-based Spatial Statistics analysis thresholded at p = 0.01. Bottom panels (B) show areas of structural connectivity that differed significantly between the schizophrenic patients and controls, on the basis of the seed placed in the genu of the corpus callosum (upper, shown in red), and the seeds placed in the body of the corpus callosum, right and left (lower, shown in orange). A threshold of p = 0.05 corrected was used for this analysis. The right side of the image represents the left side of the brain. Reprinted from Pomarol-Clotet et al. (2010). Medial prefrontal cortex pathology in schizophrenia as revealed by convergent findings from multimodal imaging. Mol. Psychiatry 15, 823–830 with permission from Macmillan Publishers Limited.