Fig. 1.

Aldh1a1 deficiency decreases fasting glucose. A, Twelve to 14-wk-old weight matched WT (open circle) and Aldh1a1^−/− mice (solid circle) on a normal chow diet were analyzed for body composition using nuclear magnetic resonance spectroscopy. B, SWAT, GWAT, and liver weights were measured immediately after dissection (WT, white bars; Aldh1a1^−/−, black bars) C, Blood glucose concentrations were determined in WT and Aldh1a1^−/− mice at random fed state and after 6 h and 18 h fasting. D and E, Glucose (GTT) and insulin tolerance tests (ITT) were performed in WT (dashed line) and Aldh1a1^−/− mice (solid line). Percent of basal glucose during GTT and ITT is given (n = 8/group; *, P < 0.05).