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Estrogen supplementation leads to reduced ERα in aged female rats. ERα-positive cells are more abundant in the ischemic cortex of intact (A) and OVX rats (B) compared with E2 rats (C). The area of the cortex represented in photomicrographs is indicated. Optical densitometry demonstrates significantly less ERα immunoreactivity in the E2 rats (D). *, P < 0.01 compared with intact; #, P < 0.01 compared with OVX. Scale bar, 50 μm.
