Activation of islet ER in vivo suppresses SREBP1c and ChREBP mRNA expression. A, Gene expression of lipogenic genes normalized to β-actin in islets of male control (ERαlox/lox) and PERαKO−/− mice treated with PPT (200 μg/d for 2 d) (n = 8–24 mice). Results represent the mean ± se. *, **, ***, vs. control vehicle. *, P < 0.05; **, P < 0.01; ***, P < 0.001.