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Effects of cyclic nucleotide or Cx43 stimulation on VSMC DNA synthesis. In rat primary VSMCs in the presence of 10% serum for 6 h, DADS (50 μM) significantly reduced the rate of DNA synthesis by 20% compared with vehicle controls estimated by BrdU incorporation. Data are mean ± SE from three independent experiments each with an n = 6. Student–Newman–Keuls method for multiple comparisons following one-way ANOVA was used. *p < 0.05compared with normalized vehicle controls.
