Table 3.
Concordance, Sensitivity, and Specificity of Genotyping Tools Taking as Reference the Trofile Assay
| Genotypic algorithms | Concordance (%) | Sensitivity (%) | Specificity (%) |
|---|---|---|---|
| 11/25 rule | 70.8 | 59 | 100 |
| Geno2phenoMotivate | 66.7 | 53 | 100 |
| Geno2pheno20clonal | 79.2 | 76 | 85.7 |
| Geno2pheno20clínicoC | 73.9 | 75 | 71.4 |
| Geno2pheno20clínicoN | 68.8 | 90 | 33.3 |
| Geno2pheno10clonal | 66.7 | 58.8 | 85.7 |
| Geno2pheno10clínicoC | 69.6 | 37.5 | 100 |
| Geno2pheno10clínicoN | 50.0 | 50 | 50 |
| PSSM | 76.2 | 64 | 100 |
| IAL criterion | 95.8 | 94 | 100 |
Agreement between Trofile results with different genotypic algorithms; geno2pheno were evaluated using different cutoffs. Values of false-positive rate, including 5.75, (motivate), 10%, and 20%, using both clonal and clinical option, the latter applying both recommended nadir TCD4 (N) and TCD4 at collection (C).