Table 2.
Major Clinical Findings and Organ Involvement in 17 Children with NOMIDa
| Patient | Neurological involvement
|
Bony overgrowth | Eye involvement | Ear involvement | Laryngeal involvement | Hematological findings | |||
|---|---|---|---|---|---|---|---|---|---|
| Increased ICP | Chronic papilledema | Chronic meningitis | Developmental delay | ||||||
| 1 | Y | Y | Y | Y | Y | Y | N | Y | |
| 2 | Y | Y | Y | N | Y | N | N | Y | Y |
| 3 | Y | Y | Y | Y | Y | Y | Y | N | Y |
| 4 | Y | N | N | Y | N | Y | N | Y | Y |
| 5 | Y | N | N | Y | Y | N | N | N | Y |
| 6 | Y | Y | N | Y | N | Y | Y | Y | Y |
| 7 | Y | Y | Y | Y | Y | Y | Y | Y | Y |
| 8 | Y | Y | N | Y | Y | Y | Y | N | Y |
| 9 | Y | Y | Y | Y | N | Y | Y | Y | Y |
| 10 | Y | Y | Y | Y | N | Y | Y | Y | Y |
| 11 | Y | N | N | N | N | Y | Y | Y | Y |
| 12 | Y | Y | Y | N | N | Y | Y | Y | Y |
| 13 | Y | Y | N | Y | N | Y | Y | N | Y |
| 14 | Y | Y | Y | Y | N | Y | Y | Y | Y |
| 15 | N | N | N | Y | Y | Y | Y | Y | Y |
| 16 | Y | Y | Y | Y | N | Y | Y | N | Y |
| 17 | Y | Y | Y | Y | N | Y | Y | N | Y |
a
Bony overgrowth includes epiphyseal and/or patellar overgrowth. All children have intermittent arthralgias and five had clubbing. Eye involvement includes uveitis, progressive visual defect, amblyopia with strabismus, photophobia, optic nerve disc elevation, redness of the eyes, or conjunctivitis. Ear involvement includes the diagnoses of hearing loss. Laryngeal involvement includes the diagnosis of true vocal cord swelling made by indirect laryngoscopy. Hematological findings include anemia, leukocytosis, thrombocytosis, or coagulation abnormalities. ICP reflects intracranial pressure.
Y, presence of the listed finding; N, absence of the listed finding.