Table 2.
Degree of neutrophil infiltration (mean ± SEM) in lung, liver, kidney, spleen, and heart after cecal ligation and puncture
Organ | Time (h) after cecal ligation and puncture | ||||||||
---|---|---|---|---|---|---|---|---|---|
NOS1+/+ | 7-NI-treated NOS1+/+ | NOS1–/– | |||||||
6 (n = 6) | 24 (n = 9) | 168 (n = 10) | 6 (n = 6) | 24 (n = 10) | 168 (n = 10) | 6 (n = 4) | 24 (n = 19) | 168 (n = 15) | |
Lung | 0 | 0.11 ± 0.11 | 0 | 0 | 0.11 ± 0.11 | 0 | 0.10 ± 0.10 | 0.07 ± 0.07 | NA |
Liver | 0 | 0.33 ± 0.24 | 0.50 ± 0.29 | 0 | 0.11 ± 0.11 | 0 | 0.40 ± 0.31 | 0.21 ± 0.11 | NA |
Kidney | 0 | 0.11 ± 0.11 | 0 | 0 | 0 | 0 | 0.30 ± 0.30 | 0.10 ± 0.43 | NA |
Spleen | 1.17 ± 0.40 | 1.11 ± 0.26 | 0.25 ± 0.25 | 1.40 ± 0.51 | 0.89 ± 0.35 | 1.00 ± 1.00 | 0.90 ± 0.28 | 0.43 ± 0.17 | NA |
Heart | 0 | 0.11 ± 0.11 | 0 | 0 | 0.11 ± 0.11 | 0 | 0 | 0.07 ± 0.07 | NA |
For explanations see Table 1