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. Author manuscript; available in PMC: 2012 Dec 1.
Published in final edited form as: Arterioscler Thromb Vasc Biol. 2011 Oct 6;31(12):2889–2896. doi: 10.1161/ATVBAHA.111.236570

Figure 2.

Figure 2

Panel a, following elastase treatment vessels continued to show pressure-induced myogenic tone (left) although acute myogenic responsiveness was blunted (right). Panel b, following elastase treatment vessels (n = 6) showed dilation to ACh (10−6 M) and constriction to phenylephrine (10−6 M) (right) comparable to that under control conditions (left). Panel c, elastase treatment caused a leftward shift in the passive pressure – diameter relationship compared to baseline indicating an increase in vessel stiffness. Panel d - collagenase treatment caused dilation of myogenically active cremaster arterioles (n = 6). This effect was reversed by washing and was in contrast to the effect of elastase which caused irreversible lengthening of the cannulated vessel segments. Results are shown as mean ± SEM, * P < 0.05.