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. Author manuscript; available in PMC: 2012 Sep 1.
Published in final edited form as: Arch Gen Psychiatry. 2011 May 2;68(9):953–960. doi: 10.1001/archgenpsychiatry.2011.51

Figure 1.

Figure 1

Secondhand smoke (SHS) exposure leads to significant α4β2* nicotinic acetylcholine receptor occupancy. A, Representative time-activity curves from before to after SHS (solid symbols) and control (open symbols) exposure (first dashed box) and after cigarette smoking to satiety (second dashed box). Cp indicates concentration of free 2-[18F]fluoro-3-(2(S)azetidinylmethoxy) pyridine (also known as 2-[18F]fluoro-A-85380, or 2-FA) in plasma. Total volume of distribution (VT) (B) and specific binding volume of distribution (VS) (C), corrected for the free fraction of plasma 2-[18F]fluoro-3-(2(S)azetidinylmethoxy) pyridine (fP). Error bars indicate SEM; ND, nondisplaceable volume of distribution corrected for fP. *P <.001; †P <.02; and ‡P <.01 (paired t test). D, Occupancy of α4β2* nicotinic acetylcholine receptors from SHS exposure. Error bars indicate SEM; average, average of the 3 regions of interest. *P <.001; †P <.02; and ‡P <.01 (1-sample t test).