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. Author manuscript; available in PMC: 2013 Jun 8.
Published in final edited form as: Mol Cell. 2012 Jun 8;46(5):691–704. doi: 10.1016/j.molcel.2012.05.028

Figure 7. Conservation of Functional Cross-talk Between Biological Processes.

Figure 7

(A) Genetic cross-talk between distinct biological processes in S. pombe. The size of each circle represents the fraction of significant interactions between two processes compared to the fraction of significant interactions between all annotated genes. Purple circles represent significant enrichment of interactions between processes. Significance is assessed using a two-tailed binomial test, and the Bonferonni method is used to correct for multiple testing. Enrichment values and p-values are given in Table S3. For the S. cerevisiae enrichment map and data see Figure S7 and Table S3. (B) Enrichments observed in S. pombe are highly correlated with the ones in S. cerevisiae. Pairs of processes that are highly connected in both species are colored purple, highlighted inside the yellow box and are drawn as a network diagram in (C). Within process enrichments (i.e. the diagonal in Figure 7A) are not shown. (C) Conserved links between biological processes. Links represent pairs of processes that are linked by at least 1.4 times the background rate of genetic interactions in both species.