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The C-terminal tail of kAE1-M909T is a class I PDZ ligand. (A) A proteomic array containing 96 putative class I PDZ domains (38) showed binding of GST-kAE1-M909T (lower panel) but not its wild-type equivalent (upper panel) to bins A2, A10, and G1 (MAGI-3, MAGI-1, and PDZK1). (B) The interaction with purified PDZK1 was confirmed by ELISA. Data are means and SEM of three experiments.
