Table 1.

Molecular markers of resistance (%)

n = 200
	I 2002-2005 (n = 139)		II 2008-2010 (n = 61)			I	II	I	II
	W	M	W	M	p	Combined genotypes
pfdhfr-51	4.3	95.7	8.2	91.8	0.3	pfdhfr-51I-59R-108N		Cuadruple pfdhf-pfdps
pfdhfr-59	5	95	8.2	91.8	0.5			51I-59R-108N-437G
pfdhfr-108	1.4	98.6	1.6	98.4	1	90.8	81.3	53.4	63.3
pfdhfr-164	100	0	100	0	1			Quintuple pfdhf-pfdps
pfdhps-436	87.7	12.3	100	0	0.004	pfdhps-437G		51I-59R-108N-437G-540E
pfdhps-437	29	71	16.4	83.6	0.05			18.4	16.3
pfdhps-540	75.4	24.6	83.3	16.7	0.2	46.7	60	51I-59R-108N-437G-581G
pfdhps-581	97.8	2.2	90	10	0.02			1	8.2
pfmdr1-86	48.5	51.5	58.6	41.4	0.1
pfmdr1-1246	64.9	35.1	91.8	8.2	0.0001
pfcrt-76	4.4	95.6	3.4	96.6	1

Wild-type (W) and mutant-type (M) alleles; I: 2002-2006; II: 2008-2010