Table 2.
10-fold cross-validation evaluation of per-residue and per-protein nonsense sequence predictors
| Specificity | Sensitivity. | Accuracy = (spec+sens)/2 | Area under curve | |
|---|---|---|---|---|
| Homo sapiens | ||||
| Per-residue | ||||
| Overall | 83.47% | 84.42% | 83.94% | 0.9189 |
| Ordered regions | 82.35% | 84.03% | 83.19% | 0.9119 |
| Disordered regions | 84.82% | 85.04% | 84.93% | 0.9276 |
| Nonsense ~ introns | 83.47% | 84.15% | 83.81% | 0.9174 |
| Nonsense ~ exons | 83.47% | 84.94% | 84.20% | 0.9217 |
| Per-protein | 94.43% | 98.81% | 96.62% | 0.9933 |
| Mus musculus | ||||
| Per-residue | ||||
| Overall | 82.28% | 83.28% | 82.78% | 0.9087 |
| Ordered regions | 81.15% | 82.94% | 82.05% | 0.9016 |
| Disordered regions | 83.69% | 83.88% | 83.79% | 0.9182 |
| Nonsense ~ introns | 82.28% | 81.92% | 82.10% | 0.9022 |
| Nonsense ~ exons | 82.28% | 85.91% | 84.09% | 0.9213 |
| Per-protein | 94.02% | 98.85% | 96.43% | 0.9938 |
| Drosophila melanogaster | ||||
| Per-residue | ||||
| Overall | 84.57% | 87.14% | 85.86% | 0.9360 |
| Ordered regions | 82.05% | 85.59% | 83.82% | 0.9187 |
| Disordered regions | 87.70% | 88.86% | 88.28% | 0.9538 |
| Nonsense ~ introns | 84.57% | 81.18% | 82.88% | 0.9105 |
| Nonsense ~ exons | 84.57% | 90.04% | 87.31% | 0.9485 |
| Per-protein | 96.97% | 97.54% | 97.26% | 0.9938 |
| Danio rerio | ||||
| Per-residue | ||||
| Overall | 83.29% | 87.12% | 85.20% | 0.9297 |
| Ordered regions | 80.80% | 88.41% | 84.61% | 0.9262 |
| Disordered regions | 86.85% | 82.38% | 84.61% | 0.9266 |
| Nonsense ~ introns | 83.29% | 88.00% | 85.64% | 0.9338 |
| Nonsense ~ exons | 83.29% | 85.47% | 84.38% | 0.9220 |
| Per-protein | 95.98% | 99.60% | 97.79% | 0.9980 |