Table 4. Lifespan extension is modular.

Gene	Na	Lifespan increase (%)b	p-value	control
Ce aakg-2(sta2)	2	48±645±10	4×10−54×10−5	unc-119(+) unc-119(+)
Dr ucp2	2	44±335±4	2×10−37×10−3	unc-119(+) unc-119(+)
Ce hsf-1	2	37±630±5	5×10−39×10−3	unc-119(+) unc-119(+)
Dr lyz	1	28±5	10−2	unc-119(+)
Dual-1[Ce aakg-2(sta2); Dr ucp2]	2	80±1084±10	8×10−35×10−3	Ce aakg-2(sta2) Ce aakg-2(sta2)
Dual-2[Ce hsf-1; Dr lyz]	2	60±957±5	2×10−44×10−4	Ce hsf-1 Ce hsf-1
Triple-1[Ce aakg-2(sta2); Dr ucp2; Dr lyz]	2	105±1097±8	2×10−44×10−3	dual-1dual-1
Triple-2[Ce hsf-1; Dr lyz; Ce aakg-2(sta2)]	2	92±1084±12	6×10−52×10−4	dual-2dual-2
Quadruple[Ce hsf-1; Dr lyz; Ce aakg-2(sta2); Dr ucp2]	2	135±14124±17	5×10−4	triple1

^aNumber of lines;

^bmedian percentage increase in lifespan ± SD (p<0.01 determined by log-rank statistics) from three independent assays. At least 80 animals were scored for each lifespan experiment; Additional data are shown in Table S7.