Table 2. Conditional analysis of the HLA-DQB1, HLA-DQA1, HLA-DRB1 locus.
Replication StudyN = 4,789 across 8 cohorts(2,228 cases/2,561 controls) | Replication and GWASN = 10,755 across 12 cohorts(5,372 cases/5,383 controls) | ||||||||
UNADJUSTED | CONDITIONED | UNADJUSTED | CONDITIONED | ||||||
OR | P-value | OR | P-value | OR | P-value | OR | P-value | CONDITIONING SNPs | |
rs9275224 | 0.75 | 4×10−11 | 0.71 | 2×10−6 | 0.72 | 9×10−30 | 0.75 | 7×10−10 | rs2856717, rs9275424, rs9275596 |
rs2856717 | 0.86 | 1×10−3 | 1.72 | 1×10−6 | 0.77 | 7×10−16 | 1.61 | 2×10−10 | rs9275224, rs9275424, rs9275596 |
rs9275424 | 1.22 | 5×10−5 | 1.06 | 3×10−1 | 1.28 | 3×10−14 | 1.11 | 7×10−3 | rs9275224, rs2856717, rs9275596 |
rs9275596 | 0.75 | 5×10−9 | 0.64 | 2×10−6 | 0.67 | 5×10−32 | 0.58 | 3×10−16 | rs9275224, rs2856717, rs9275424 |