Table 5. The comparison of the original and the newly refined IgAN risk score.

		Original Risk Score				Newly Refined Risk Score
Cohort:	N#	R2 *	C**	OR***	P-value****	R2 *	C**	OR***	P-value****
Original GWAS Cohorts	5,631	5.0%	0.61	1.51	3.1×10−46	5.7%	0.62	1.56	4.1×10−52
Replication Cohorts	4,422	2.2%	0.58	1.29	5.4×10−17	3.2%	0.59	1.36	3.3×10−24
Asian Cohorts Combined	4,582	4.5%	0.60	1.53	3.0×10−34	5.0%	0.61	1.52	2.6×10−38
European Cohorts Combined	5,386	2.6%	0.58	1.34	3.7×10−24	3.6%	0.59	1.42	6.7×10−33
All Cohorts Combined	10,053	3.8%	0.60	1.42	6.2×10−63	4.7%	0.61	1.47	1.2×10−76

The expanded version of this table can be found in supplemental material (Table S7).

^#Number of analyzed individuals with 100% non-missing genotypes across all 7 scored loci.

*: 2: Nagelkerke R square (expressed as percentage).

**: C-statistic: area under the ROC curve.

***: Odds ratio per one standard deviation of the standardized risk score.

****: Wald's test for risk score as a quantitative predictor of disease status.