Table 2. Molecular and cellular functions, and diseases and disorders overrepresented among the genes disrupted in familial breast cancer cases.
| Molecular and cellular functions | P-valuesa | Genes involved |
| Organization of chromosomes | 0.0133 | BLM, DCLRE1C |
| Maintenance of telomeres | 0.0133 | BLM, DCLRE1C |
| Repair of DNA | 0.0178 | RECQL4, BLM, DCLRE1C |
| Double-stranded DNA break repair | 0.0211 | BLM, DCLRE1C |
| Quantity of corpus luteum | 0.00367 | CASP3, ESR2 |
| Diseases and disorders | ||
| Diabetes mellitus | 0.000268 | ACSL1,ANKS1B,ARHGAP39,BLM,CASP3,ESR2,KCNIP4,KLHL1,MARCH6,MLF1IP,RBFOX1,STRN,SYNE2 |
No particular functions were overrepresented among controls.
a
Statistically significant false discovery rate (FDR) adjusted P-values; correction for multiple testing was done using the Benjamini-Hochberg method.