Table 4. Longitudinal association between FEV1 rate of decline, smoking and African ancestry, among African American participants in the Health ABC study.
FEV1 (ml/yr) | |||
(N = 1,737) | |||
Variable | Beta | SE | P value |
Model 1 † | |||
Intercept | 1630.22 | 58.43 | <0.001 |
African ancestry, % | −2.90 | 1.40 | 0.04 |
Age, year at time t | −26.45 | 10.18 | 0.01 |
Smoking, pack-years | −4.60 | 0.79 | <0.001 |
Age*African*Pack-years | 0.007 | 0.004 | 0.14 |
Model 2 | |||
Intercept | 1629.17 | 58.66 | <0.001 |
African ancestry, % | −4.37 | 1.70 | 0.01 |
Age, year at time t | −31.55 | 2.24 | <0.001 |
Smoking, pack-years | −4.61 | 0.77 | <0.001 |
Age*African*Former smoker | 0.32 | 0.23 | 0.16 |
Age*African*Current smoker | 0.12 | 0.43 | 0.78 |
Mixed effects models are adjusted for sex, standing height, household income, clinic site and two-way interactions among covariates. Age, height and African ancestry are mean centered.
Model 1 is also adjusted for smoking status.