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YC-1 induced dose-dependent retinal ganglion cell (RGC) cell death. A: RGC-5 cells were exposed to 5, 10, 20, and 40 µM YC-1 and 0.066% DMSO for 24 h. Morphological changes in cell density were observed with light microscopy. B: Cell viability was detected with an MTT assay of increasing the YC-1 concentration to treat RGC-5 cells. * Indicates p<0.05 compared to the DMSO vehicle group.
