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. 2012 Jun 21;8(6):e1002755. doi: 10.1371/journal.ppat.1002755

Figure 8. The RON2 cystine loop governs specificity.

Figure 8

(A). Alignment of RON2 sequences truncated to correlate PfRON2sp1 with RON2 sequences from the following accession numbers: TgRON2 - TGME49_100100, NcRON2 - NCLIV_064620, PfRON2 - PF14_0495, PvRON2 - PVX_117880, PyRON2 – PY_06813, BbRON2 (BBOV_I001630). (B). Overlay of TgRON2sp (green; PDB ID 2Y8T) onto PfAMA1-PfRON2sp (blue-orange) shows that both peptides adopt a helix/coil/cystine loop/coil architecture in the AMA1 groove, with the highest divergence localized to the cystine loop (black arrow). (C). Electrostatic surface renderings of PfAMA1 (left) and TgAMA1 (right), with the secondary structure of the RON2 binding partner and residues defining the base of cystine loop shown, illustrates that both interactions are highly complementary, but highly genus specific.